Cilosta
Tablet
Generic Name
Cilostazol
Strength
100 mg
Manufacturer
Square Pharmaceuticals PLC
Unit Price
Unit Price: ৳ 12.09 (3 x 10: ৳ 362.70) Strip Price: ৳ 120.90
🔹 Indications
Cilosta is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. Intermittent claudication, also known as vascular claudication, is a symptom that describes muscle pain (pain, cramps, numbness, or a feeling of fatigue) during light exertion.
🔹 Pharmacology
Cilostazol is a preparation of Cilostazol which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
🔹 Dosage & Administration
The recommended dosage of Cilostazol is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.
Pediatric use: The safety and effectiveness of Cilostazol in pediatric patients have not been established.
Pediatric use: The safety and effectiveness of Cilostazol in pediatric patients have not been established.
🔹 Interaction
Pharmacokinetic studies have demonstrated that Omeprazole and Erythromycin significantly increased the systemic exposure of Cilosta and/or its major metabolites. Population pharmacokinetic studies showed higher concentrations of Cilosta among patients concurrently treated with Diltiazem.
🔹 Contraindications
Cilostazol is contraindicated in patients with congestive heart failure of any severity. Cilostazol is also contraindicated in patients with known or suspected hypersensitivity to any of its components.
🔹 Side Effects
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
🔹 Pregnancy & Lactation
There are no adequate and well controlled studies in pregnant women. Transfer of Cilostazol into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Cilostazol.
🔹 Precautions & Warnings
Cilosta should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Cilosta and Clopidogrel.
🔹 Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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💡 Frequently Asked Questions
Cilosta is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. Intermittent claudication, also known as vascular claudication, is a symptom that describes muscle pain (pain, cramps, num...
The recommended dosage of Cilostazol is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin,...
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
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